Perinatal factors and high-sensitive C-reactive protein levels during adolescence

Objective To examine whether perinatal factors are associated with low-grade inflammation measured by high-sensitivity C-reactive protein levels during adolescence. Methods Nested case-control study of 125 teenagers who were born Cesarean delivery and had determined at 15–17 years. Data on obstetric recorded prospectively the time their birth. Results Median values significantly higher in teenagers, as large for gestational age or maternal diabetes compared to others (2.54 vs 0.34 mg/L; p < 0.024), spring summer those winter autumn (0.48 0.27 0.023). No other associations detected (for ex. such electivity operation, onset labor, rupture fetal membranes, cervical dilatation delivery, age, Apgar scores 5 min, umbilical blood pH value, administration neonatal antibiotics need intensive care treatment) CRP levels. Further, current body mass index highest tertile, regular medication chronic disease girls using oral contraceptives than others. Conclusion Prenatal exposures metabolic environment seasonality may have longterm effects later cardiometabolic risks. Seasonality might be partly explained vitamin D pregnancy, thus future efforts warranted ensure sufficient availability pregnancy. Surprisingly, no significant between characteristics